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A virus contracted through oral sex is the cause of some throat cancers, say U.S. scientists.
A study by Johns Hopkins University conducted on 300 people found that HPV infection was a major risk factor that the use of alcohol or snuff.
The study, published in the journal New England Journal of Medicine found that the risk was almost nine times greater for those who reported oral sex with more than six people.
However, experts cautioned that it takes a larger study to confirm these findings.
HPV infection causes most cervical cancers and 80% of sexually active women can expect to have an HPV infection at some point in their life.
Family history
The Johns Hopkins study took blood and saliva from 100 men and women newly diagnosed
with oropharyngeal cancer which affects the throat, tonsils and the front of the tongue.
It is important for health care providers to know that people without traditional risk factors for snuff and alcohol use can nevertheless be at risk of oropharyngeal cancer
Doctor D'Souza Gypsamber
Also asked about sexual practices and other risk factors for disease such as family history.
Those who had evidence of prior oral HPV infection were 32 times higher risk of throat cancer.
HPV16, one of the most common strains of the virus causing cancer, was present in the tumors of 72% of cancer patients in the study.
Risk Factors
There was no added risk for people infected with HPV who also smoked and drank alcohol, suggesting that the virus itself is driving the risk of cancer.
Oral sex was described as the main mode of transmission of HPV but the researchers said mouth-to-mouth transmission, for example through kissing, could not be ruled out.
People should know that oropharyngeal cancer is relatively uncommon and the vast majority of people with oral HPV infection probably will not develop throat cancer
Dr. Maura Gillison
Most HPV infections are cured with few or no symptoms, but a small percentage of people who acquired high-risk strains may develop cancer, researchers said.
The study's author, Dr. Gypsamber D'Souza said: "It is important that health services know that people without traditional risk factors for snuff and alcohol use may be, however, at risk of oropharyngeal cancer."
The Co-researcher Dr Maura Gillison said previous studies suggested a strong link.
But he added: "People should know that oropharyngeal cancer is relatively uncommon and the vast majority of people with oral HPV infection probably will not develop throat cancer."
A vaccine that protects against cervical cancer caused by strains 6, 11 and HPV 18 is available, and researchers say the study provides a rationale for vaccinating both men and women.
However, it is not known whether the vaccine would protect against oral HPV infection.
January 20th, 2012 at 7:36 am
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